Which areas of the body are most commonly affected by osteitis deformans?

Osteitis deformans, also known as Paget's disease of bone, primarily affects the areas where there is a high concentration of bone remodeling, which tends to involve the skull, spine, pelvis, and legs. These regions are subject to more significant metabolic activity in bone tissue, resulting in the characteristic abnormalities seen in Paget’s disease.

In the skull, the disease can lead to enlarged and misshapen bones, and in the spine, it can affect the vertebrae, potentially leading to pain and neurological complications due to spinal compression. The pelvis is also substantially impacted, which can lead to issues with mobility, and the legs are commonly affected, where deformation can lead to bowing or other alignment problems.

Understanding the areas affected by osteitis deformans is crucial for diagnosing and managing the condition effectively, as symptoms can vary significantly depending on the specific bones involved and the extent of the disease.