What symptom is most commonly associated with multiple myeloma?

Bone pain is the symptom most commonly associated with multiple myeloma due to the disease's impact on bone health. Multiple myeloma is characterized by the proliferation of abnormal plasma cells in the bone marrow, which can lead to the weakening of bone structure. As these malignant plasma cells accumulate, they can cause bone lesions, contributing to pain, fractures, and general discomfort in various locations.

This bone pain may be diffuse or localized, often presenting in the spine, ribs, or pelvis. It is a predominant complaint among patients and is an essential consideration in both diagnosis and management of the disease. Other associated symptoms may occur, but bone pain stands out as a hallmark of the condition, directly linked to the underlying pathophysiology affecting the skeletal system.