What complication can arise from multiple myeloma due to bone marrow destruction?

Multiple myeloma is a malignancy of plasma cells in the bone marrow that leads to the destruction of bone tissue. One of the significant complications associated with this condition is osteoporosis, which is characterized by a decrease in bone density and an increased risk of fractures.

As myeloma cells proliferate in the bone marrow, they interfere with the normal processes of bone remodeling. Healthy bone is continuously broken down and rebuilt, but the presence of myeloma disrupts this balance, leading to increased bone resorption, where bone is broken down faster than it can be rebuilt. This results in the weakening of bones, making them more susceptible to fractures and the overall development of osteoporosis.

The other options do not directly relate to the primary consequence of bone marrow destruction in multiple myeloma. While conditions like osteosarcoma (a type of bone cancer) and neuropathy (often related to other factors such as chemotherapy) may arise in patients with multiple myeloma, they are not direct complications of the bone marrow destruction caused by the disease itself. Amputation is also not a common or direct consequence of multiple myeloma-related complications, as the focus is more on managing bone health to prevent fractures rather than surgical interventions like amputation.